By place
Byzantine Empire
- January 1 – Anicius Faustus Albinus Basilius is appointed as consul in Constantinople, the last person to hold this office.
- Plague of Justinian: Bubonic plague appears suddenly in the Egyptian port of Pelusium, spreading to Alexandria and, the following year, to Constantinople. This is the beginning of a 200-year-long pandemic that will devastate Europe, the Middle East, and North Africa.
- Emperor Justinian I recalls Belisarius from Italy to handle the situation in Armenia. He arrives in Upper Mesopotamia and attacks the fortress city of Nisbis. After an unsuccessful siege he ravages the countryside.[1][full citation needed]
- John the Cappadocian, praetorian prefect of the East, is dismissed by the Byzantine empress Theodora for treason. He is banished to Cyzicus, and his estates are confiscated.[2][3]
Europe
- Autumn – Totila is elected king by the Ostrogothic nobles after the death of his uncle Ildibad. He wins the support of the lower classes by liberating slaves and distributing land to the peasants.
- Winter – Siege of Verona: Totila defends the city of Verona against a numerically superior Byzantine army. He gains control over the Po Valley and prepares a Gothic offensive in Central Italy.
Persia
- Lazic War: King Khosrau I intervenes in Lazica (modern Georgia), and supports the weakened king Gubazes II against a full-scale uprising. He sends an expeditionary force under Mermeroes and captures the Byzantine stronghold of Petra, located on the coast of the Black Sea, which provides the Persians a strategic port.[1][full citation needed]
Asia
- The Uyghurs come under the rule of the Hephthalites (approximate date).
By topic
Religion
- Jacob Baradaeus becomes bishop of Edessa (approximate date).
