Roman Empire
- The Roman Empire is threatened on several fronts at the same time. Africa revolts and tribes in northwest Germania, under the name of the Franks, are raiding the Rhine frontier.
- Rome becomes 1,000 years old. The 1,000th anniversary is commemorated with the Ludi Saeculares festivals, celebrated throughout the Roman Empire.
- The Goths appear on the lower Danube frontier; they invade Ukraine and Romania.
Persia
- Prince Shapur I becomes co-ruler of the Sasanian Empire with his father King Ardashir I.
- Siege of Hatra: The Sasanians besiege the capital of the Kingdom of Hatra ruled by Sanatruq II.
- Prince Shapur I succeeds his father Ardashir I as ruler of the Sassanid Empire. He begins his expansion in India.
India
- Maharaja Sri-Gupta becomes ruler of the Gupta Empire (approximate date).
Religion
- Mani, a young mystic of Ctesiphon, proclaims himself a prophet at the court of Ardashir I. He preaches his doctrine, Manichaeism, throughout the Sassanid Empire.
